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Dear Editor, we recently read with interest the article by Saludares et al., “A Phase 1 Randomized Trial of Topical Insulin for Glaucoma”, which was published in Ophthalmology Science.1 The team’s research may represent a new step toward developing intraocular pressure (IOP) independent treatments for glaucoma. Given the importance and novelty of the article, we have a few considerations and questions for the research team that may also be helpful for subsequent phases of the study: